Can we cure HIV with an injection?

HIV was thought to be incurable, but after undergoing risky stem cell transplant surgeries, several patients no longer exhibit the deadly virus. Scientist Dr. Hans-Peter Kiem takes that idea a step further and shares his pioneering research using new gene-editing techniques. His bold vision may one day allow patients anywhere in the world to receive a single injection to stop HIV and other deadly diseases in their tracks.

Special thanks to core the TEDxSeattle organizing team, 100+ volunteers, and our generous partners – without you, this experience would not be possible. Find out more about our talks, speakers, entertainers, activities, and year-round events at TEDxSeattle.com.

In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TED Talks video and live speakers combine to spark in-depth discussion and connection in a community setting. These events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.

Hans-Peter, the Director of the Stem Cell and Gene Therapy program at the Fred Hutchinson Cancer Research Center, is known as a pioneer in the development of new gene-editing technologies. Through his work as an oncologist providing bone marrow transplants to leukemia patients, Dr. Kiem learned it’s possible to modify genes in blood marrow stem cells and convey those genetic changes to a patient.

Hans-Peter and his team hope to achieve cures for diseases like HIV, cancer, sickle cell anemia, and other blood disorders with this ability to repair or modify genes by editing stem cells to carry healthier or disease-resistant versions of genes before transplant. He is currently pioneering “in vivo” and “ex vivo” approaches to make gene therapy and gene editing more broadly available and accessible to those living with HIV, especially in resource-limited settings.

He received his M.D. and Ph.D., at the University of Ulm in Germany. Hans-Peter came to the United States in 1988 and completed research at Stanford University. He received a degree in internal medicine at Vanderbilt University before an oncology fellowship at the University of Washington led to his work with the Fred Hutch.

This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx

Dr. Hans-Peter Kiem, the Director of the Stem Cell and Gene Therapy program at the Fred Hutchinson Cancer Research Center, is known as a pioneer in the development of new gene-editing technologies. Through his work as an oncologist providing bone marrow transplants to leukemia patients, Dr. Kiem learned it’s possible to modify genes in blood marrow stem cells and convey those genetic changes to a patient.

Dr. Kiem and his team hope to achieve cures for diseases like HIV, cancer, sickle cell anemia and other blood disorders with this ability to repair or modify genes by editing stem cells to carry healthier or disease-resistant versions of genes prior to transplant. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx


Finding balance in bipolar

Ellen Forney is a passionate storyteller and artist who turned her bipolar diagnosis into a platform of hope for anyone struggling with mental health issues. In this moving and generous talk, Ellen uses both words and pictures — her own comics —to share the story of how she maintained her creativity while managing her illness and shares the system she developed for achieving balance and keeping it.

Special thanks to core the TEDxSeattle organizing team, 100+ volunteers, and our generous partners – without you, this experience would not be possible. Find out more about our talks, speakers, entertainers, activities, and year-round events at TEDxSeattle.com.

In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TED Talks video and live speakers combine to spark in-depth discussion and connection in a community setting. These events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.

Ellen is an artist, teacher, and mental health advocate. She is the author of the New York Times bestselling graphic memoir, Marbles: Mania, Depression, Michelangelo, & Me, the story of her diagnosis and struggle with bipolar disorder, and Rock Steady: Brilliant Advice from My Bipolar Life, a guide to maintaining mental health. Rock Steady was featured in the Journal of American Medical Association (JAMA)’s “Best of Graphic Medicine 2018”, and the book’s self-care framework is widely used by therapists and clinicians. Ellen also curated the National Library of Medicine’s traveling exhibition on Graphic Medicine, a new genre of comics about health.

This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx

Ellen Forney is a cartoonist, teacher, and mental health advocate. She is the author of the New York Times bestselling graphic memoir, Marbles: Mania, Depression, Michelangelo, & Me, the story of her diagnosis and struggle with bipolar disorder, and Rock Steady: Brilliant Advice From My Bipolar Life, a guide to maintaining mental health. Marbles has been printed in seven foreign editions and translated into six different languages and was selected as the Common Read for the University of Washington’s Health Sciences schools in 2018. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx


The Future of Pain Relief

Using virtual reality (VR) to treat pain has delivered exciting results, thanks to research conducted by Dr. Sam Sharar. A professor of anesthesiology and pain medicine at the University of Washington, Sam explains how “pain is all in our heads”: our physical, cognitive, and emotional reactions in the brain combine to tell us we are experiencing pain. The reality of pain is entirely variable, unpredictable, and different for each person, making it hard to manage. Hearing the success of VR in other fields, Sam is now exploring the impact of applying VR to burn patients in an effort to alleviate the excruciating pain of their necessary treatments. The results of his studies are compelling. Getting relief from pain could come from leveraging the brain’s ability to leave the reality of pain for another reality that encourages healing—a promising concept across the field of medicine. Sam Sharar, MD, refers to himself as “an academic anesthesiologist.” He is a board-certified anesthesiologist and cares for seriously injured children and adults at Harborview Medical Center. He is also a Professor of Anesthesiology and Pain Medicine at The University of Washington. Dr. Sharar teaches and advises medical students as a College Faculty Mentor and is Vice Chair for Faculty Affairs and Development of Anesthesiology and Pain Medicine. Additionally, he is the Associate Medical Director for King County Medic 1, where he provides training to paramedics. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx


Regrowing heart muscle with stem cells

Heart disease is the number one killer in the world, but researchers are evolving a new branch of medicine to tackle the issue. For over 20 years, Dr. Chuck Murry has studied the causes of cardiovascular disease and researched harnessing the potential of stem cells to repair damaged heart muscle. In this talk, he shares his journey and groundbreaking research, providing hope through evidence that we can heal the heart. Dr. Chuck Murry is a physician-scientist at the University of Washington, where he founded and currently directs the Institute for Stem Cell and Regenerative Medicine. Heart failure—now the number one cause of death worldwide—is the motivation behind Murry's specialized research into innovative treatments. Murry believes that it is not enough simply to help a patient, plagued with chronic disease survive. Instead, his pioneering work seeks to harness the potential of human stem cells to eliminate the disease from the body. While Murry feels that, even after his 31 years in the field, there is still a great deal of work to accomplish, achieving this vision is definitively much closer today This talk was given at a TEDx event using the TED conference format but independently organized by a local community.


Back of the room at The Riveter as the audience watches TEDxSeattleLive on the large screen

TEDxSeattleLive: Watching TED 2018 "The Age of Amazement"

 

To introduce TED2018, TED owner Chris Anderson and TED Head of Curation Helen Walters asked the audience to complete a simple task: to turn to someone whom they didn’t know and state what, over the last year, the main emotion is that they’ve felt. In Seattle, the crowd that was gathered at TEDxSeattleLive followed suit. Strangers exchanged quick greetings and with just a few minutes for the exercise began sharing their hope—and fears—from the past year.  Looking from the back of the audience during TEDxSeattleLive 2018 held at The Riveter

While there was plenty of apprehension in the crowd, there was also hope for what the next year would bring despite an increasingly divisive global culture. Seattle has long been known as a city filled with forward-thinking innovation and passion for change, so it’s no surprise a day full of learning and inspiration was met with such an openness to how an idea can shape the future.

The event screened two different sessions over the course of the day: “Doom. Gloom. Outrage. Uproar.” then “Wow. Just wow.” Between the two sessions, the audience listened to topics ranging from the #MeToo movement by Tracee Ellis Ross, to how artificial intelligence can upheave the job market as we know it today by Kai-Fu Lee.


Setting scientific research free

The results from taxpayer-funded, scientific research are often locked behind a paywall.

Jennifer Hansen, a senior officer in Knowledge and Research at the Bill and Melinda Gates Foundation, says the cost of accessing that data is too high. Limiting access to the research results in social inequity and puts human lives at risk. She argues that the current model of research distribution is overdue for disruption. Hansen says it’s time to foster a scientific revolution through open access to data. Jennifer Hansen is an equity advocate with a fierce dedication to ensuring information and scientific knowledge is free and available to all. Her professional career has revolved around closing the digital divide and inspiring others to believe in the power of knowledge to shape their world. Ms. Hansen currently works at the Bill & Melinda Gates Foundation as the Senior Officer for Knowledge & Research. She drives the strategy development and management of the foundation’s research outputs and is an influencer in shaping the future of scholarly communication. She championed and led the implementation of the Foundation’s groundbreaking Open Access Policy – a policy requiring that all its funded published research be immediately available to everyone, everywhere without barrier or restriction. Nature called the bold action to open up scholarly research the”world’s strongest policy on open access research.” And, The Economist described it as “something that may help to change the practice of science.”


A powerful strategy for disrupting child trafficking

Patty Haven Fleischmann is successfully combating child trafficking in Seattle and catalyzing similar nationwide efforts.

As a therapist, child of a Holocaust survivor, and “kid advocate,” Fleischmann uses her ability to hold two opposing truths to attract a diverse and committed community and disrupt a seemingly insurmountable problem. Launching a Seattle-based non-profit which has raised $4.5 million to fund local organizations that combat both supply and demand, Fleischmann is galvanizing the community and driving a national conversation.   A licensed marriage and family therapist of 25+ years, Patty is the co-founder and President of the StolenYouth board. StolenYouth’s mission is to support the rescue and recovery of our community’s sexually exploited youth. Patty and StolenYouth have worked tirelessly to build a unique coalition of organizations fighting trafficking on all fronts. Since then, these organizations have pioneered new ways to disrupt the scope and nature of child trafficking. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.


Disease eradication is within reach

Steve Davis is working to bring an extraordinary vision to reality—the global elimination of some of the world’s most deadly and debilitating diseases.

Davis is the president and CEO of PATH, a 40-year-old, Seattle-based, global health-focused, non-governmental organization which works on vaccines, drugs, diagnostics, devices, and system/service innovations. In this talk, Davis lays out the “how to” of disease elimination calling on his diverse experience as a former human-rights lawyer, a nationally-recognized technology business innovator and social activist. Steve Davis, president and CEO of PATH, combines extensive experience as a technology business leader, global health advocate, and social innovator to accelerate great ideas and bring lifesaving solutions to scale. Prior to joining PATH in 2012, he served as director of Social Innovation at McKinsey & Company, CEO of the global digital media firm, Corbis, interim director of the Infectious Disease Research Institute, and he practiced law at the international law firm K&L Gates. Earlier, he worked extensively on refugee programs and policies, and Chinese politics and law. Mr. Davis is a lecturer on social innovation at the Stanford Graduate School of Business. He currently is a member of the Council on Foreign Relations, serves on the board of InterAction, and sits on several advisory groups, including the World Economic Forum’s Global Agenda Council on Social Innovation and the Clinton Global Initiative’s Global Health Advisory Board. He also serves as a trustee of the World Economic Forum’s Global Health Challenge. Mr. Davis earned his BA from Princeton University, his MA in Chinese studies from the University of Washington, and his law degree from Columbia University. He also studied at Beijing University.


Nature's internet: how trees talk to each other in a healthy forest

This fascinating talk presents the scientific research that shows the interconnectedness of life in the forest ecosystem.

It takes us beneath the forest floor where we learn how trees are communicating and exchanging resources. Going beyond the simple view of a forest as a resource to be exploited, it presents the forest as a complex network of life. Her examination of the relationships that make up the complexity of nature present compelling support for the idea that “We are all one”


Surviving Cancer: The Biology of Luck

Why are some people "cured" of cancer while others deal with relapses? Answering that question may mean changing the way we think about the disease.


What's wrong with dying?

The answer might seem simple, but in the hands of Lesley Hazleton, the question takes us on a surprisingly humorous and thought-provoking journey into what it would actually mean to live forever. And whether we’d truly want to. A frequent TED.com speaker and 'Accidental Theologist,' Hazleton uses wit and wisdom to challenge our ideas not only about death, but about what it is to live well.


Cubicles don't work. How architectural design affects your brain.

Scott explains how architectural design can solve--or make---problems. Citing shapes, materials and plants as just a few of the design elements that make a workspace truly work, he shows how his architecture firm's corporate projects designed with employees and the neighborhood in mind.